NMR Hits the Big Time
نویسنده
چکیده
When it comes to structural biology, bigger really is better. Most biological processes are performed by enormous multicomponent complexes, such as the ribosome. To solve the structures of these monsters, biologists traditionally have used two different but complementary techniques, nuclear magnetic resonance (NMR) and X-ray crystallography. They have had considerable success using the latter technique for protein structure determination, but the former technique has lagged behind, in part because it has not been possible to apply NMR to proteins larger than about 30,000 daltons (Da).
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